Several features affect mainly the eastern two-thirds of the country with rain, storms, and even some snow.
First, a low-pressure system will be in New England, and another in southern TX, and these systems will be connected by a front. The system in New England will produce widespread precipitation through tonight, then diminishing early on Saturday. Much of the precipitation will be rain, however, snow could mix in at times this afternoon and night with some completely changing over the snow potentially for a period of time. Some in parts of NY, VT, and NH could even pick up an inch of wet snow accumulation. As for the system in TX, it will not really move much until late Saturday night or early Sunday when it heads towards the MS River Valley. Widespread heavy rain is the main threat with these showers and embedded storms, though s spotty severe storm cannot be ruled out with some of the stronger storms. Widespread rain totals over 2 inches are expected across a good chunk of TX with some in south-central and southeast TX getting into the 3-7 inch range before things wane down.
Heading back to New England two more systems will bring precipitation chances back to this region Saturday night and Sunday night.
Finally, frontal boundaries will produce scattered showers with a few storms from the Northern Rockies to the Upper Midwest over the weekend, and a few storms could become strong Sunday evening into Sunday overnight from northeast KS to southeast WI as the front draped in this region is expected to gain strength throughout Sunday into Sunday night.